![]() Iyer R.K., Chiu L.L.Y., Reis L.A., Radisic M. Health Resources and Services Administration: Scientific Registry of Transplant Recipients OPTN/SRTR 2018 Annual Data Report: Heart. Heart Disease and Stroke Statistics-2009 Update. Lloyd-Jones D.M., Adams R., Carnethon M., De Simone G., Ferguson T.B., Flegal K.M., Ford E., Furie K., Go A. However, electrospinning commonly produces two-dimensional (2D) membranes, which limits the application of nanofibers for the 3D tissue engineering scaffold. ![]() Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Electrospun nanofibers have been used for various biomedical applications. This presents a functional limitation to their use in cardiac TE, and research aiming to address this limitation is presented in this review.Ĭardiac tissue engineering cardiomyocytes electrospinning engineered heart tissue induced pluripotent stem cells scaffolds tissue engineering.īenjamin E.J., Virani S.S., Callaway C.W., Chamberlain A.M., Chang A.R., Cheng S., Chiuve S.E., Cushman M., Delling F.N., Deo R., et al. iPSCs theoretically offer the capacity to generate limitless numbers of CMs for use in TE hearts, however these iPSC-CMs are electrophysiologically, morphologically, mechanically, and metabolically immature compared to adult CMs. Electrospinning is an attractive fabrication method for cardiac TE scaffolds because it produces fibers that demonstrate the optimal potential for mimicking the complex structure of the cardiac extracellular matrix (ECM). This review presents the requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) towards applications to TE hearts. Cardiac TE is focused on developing cardiac cells, tissues, and structures-most notably the heart. Tissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional tissues for repair or replacement of tissues and organs.
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